多半是pathinfo的问题，按下面配置可以禁用。
修改/usr/local/nginx/conf/vhost对应域名配置文件，注释掉try_files $uri =404; 并将include pathinfo.conf;注释去掉

include typecho.conf;
\#error_page 404 /404.html; location ~ ¹.php(/|$) {

\# comment try_files $uri =404; to enable pathinfo
\# try_files $uri =404;
fastcgi_pass unix:/tmp/php-cgi.sock;
fastcgi_index index.php;
include fastcgi.conf;
include pathinfo.conf; }